QuartzBio Contextualize Biomarker Data Decades Experimental Results Image 2021

How to Use Technology to Contextualize Biomarker Data Within Decades of Experimental Results for Intuitive Biological Insight Generation

July 29, 2021 — Translational research teams producing large datasets from biomarker-rich trials quickly face the next challenge: generating actionable insights from their data.

As we described in a previous case study, we have been working with many teams to enable deep mechanistic insight generation from their biomarker data to aid in signature development for selecting patients, predicting therapeutic response, and informing key development decisions.

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Biostatistics Biomarker Data Article 2 Featured Image

A Technology-Driven Solution for Optimized Statistical Analysis of Clinical Trial Biomarker Data

May 19, 2021 — Biomarker data generated to support clinical development has multiple roles:

  1. Inclusion in end-of-study regulatory submissions. As such, data must conform to FDA data exchange standards and need SDTM programming for analysis and submission.
  2. Supporting on-study decisions. Data must be stored in an accessible, flexibly structured format to adapt to on-study needs. These diverse needs include data visualization, mock TLFs, materials for investor meetings, posters, and reporting for safety review, data monitoring, and dosing decisions.
  3. Enable deep exploration to generate translational insights. Biomarker data generated during clinical trials presents opportunities for sponsors to further characterize mechanism Read More →
Immunotherapy Response signature genomics hot cold tumors QuartzBio

Translational Intelligence: Exploring Immunotherapy Response Signatures with Clinical Trial Genomics Data

May 5, 2021 — As the data generated during a modern clinical trial has dramatically expanded, sponsors must continuously evaluate novel approaches to help bridge the gap between millions of data points and breakthrough scientific insights (a goal we describe as delivering Translational Intelligence). One such example is assessing signatures of “hot” and “cold” tumors.

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May 12 webinar Exploring IO Signatures QuartzBio

Webinar On Demand: Exploring IO Signatures in Clinical Trial Genomic Data

Watch the webinar on demand:

Title: Translational Intelligence: Exploring IO Signatures in Clinical Trial Genomic Data

Duration: 30 minutes

You will learn how to:

  • Visualize gene alterations and tumor mutational burden (TMB) using heatmaps and tables, with subject and time point granularity. ​
  • Identify genes of interest and candidate signatures using visualization and statistical methods to relate clinical response data and gene expression data to regions of genomic alteration.​
  • Correlate genomic data with known signatures of immuno-oncology (IO) response through integrations with public data, knowledgebases and sponsor data.​
  • Define patient subgroups to generate deeper Read More →