COVID-19 Data Initiative2021-02-08T17:22:00-05:00

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Centralizing PK, Clinical, and Exploratory Data to Advance Biomarker Operations and Translational Intelligence

COVID-19 Data Initiative, Trends & Insights|

September 24, 2020 — The COVID-19 pandemic has forced clinical trial stakeholders to rethink the paradigm as sponsors adapt to site restrictions, remote monitoring, and updated regulatory guidance. This is especially true in precision medicine programs, which have developed global footprints in order to reach targeted patient populations and rely on specialty labs running complex assays to assess safety, characterize patient response and drug MoA, and provide insights into efficacy. In the absence of consistent and predictable in-person presence, how can sponsors maintain the timely visibility necessary to optimize operations of these complex trials?

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Interferon Signaling in COVID-19 Infection

COVID-19 Data Initiative, Trends & Insights|

June 8, 2020 — As the QuartzBio team’s efforts have progressed with the selection and integration of SARS-CoV-2 / COVID-19 data sets, I am pleased to share our first public update on analysis. This work builds on an evaluation of IFN-α2b treatment, and supports the rationale that interferons are upregulated as part of the antiviral defense, specifically for COVID-19. We are also sharing this work as a demonstration of the potential for translational research and drug repurposing while mitigating the time, expense, and reproducibility challenges inherent in drug/treatment combination discovery. This need for speed and flexibility is, of course, at the top of our minds as we respond to the global pandemic.

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Learning more about how COVID-19 affects children

COVID-19 Data Initiative, Trends & Insights|

May 20, 2020 — With new information around SARS-CoV-2 and COVID-19 surfacing on an almost daily basis, we are consistently reminded of the complexity and relatively unknown mechanisms behind why this disease presents with such a varying degree of severity. The impacts of COVID-19 infection on pediatric patients have been of particular concern in recent weeks given the apparent links of a severe Kawasaki-like disease, Pediatric Multisystem Inflammatory Syndrome (PMIS), coinciding with the pandemic. Incidence has been reported in the US and worldwide, with ~100 reports and three deaths in New York and the description of a broader outbreak in Italy outlined here.

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Multi-Layered Processing Pipelines for Data Integration

COVID-19 Data Initiative, Trends & Insights|

May 18, 2020 — As the research community is generating data from novel research and looking to leverage prior research (e.g., MERS, SARS), there is significant opportunity to integrate these diverse data sources to create an even more valuable data asset for scientific insight generation. This opportunity requires addressing very real data wrangling challenges.

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Contextualizing SARS-CoV-2 Infection With Host Biology

COVID-19 Data Initiative, Trends & Insights|

May 6, 2020 — Following Scott Marshall’s announcement last week about the QuartzBio team’s COVID-19-Related Data Aggregation Initiative, we wanted to share additional context behind the scope of our efforts. Our initial focus is creating a valuable and thoughtfully constructed data ecosystem, which will result in the ability to draw meaningful context. This is nucleated with published data from critical SARS-CoV-2 profiling experiments, that compare infection of cell line and animal models with novel coronavirus to other viruses like SARS-CoV, MERS-CoV and H1N1.

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