Quartz Bio is a Swiss-based company providing clinical bioinformatics services to the health sector. We use computational tools and biotechnological knowledge to analyse biomarker data from clinical trials. Our services are aimed at identifying subjects who will respond better to drugs, uncovering clinical biomarkers of interest and better understanding underlying disease mechanisms.
How we work +
Transparency of service and Reproducible Research are fundamental values of all that we do.
Biology first +
Biological data are not just numbers. We use our biological and biotechnological expertise to look beyond the numbers and provide documented answers to biological hypotheses.
Reproducible research +
All the steps of our analyses are reproducible and auditable. We keep track of all the operations performed on data, from reception to reporting. Our processes are governed by documented standard operating procedures. We are ISO9001 certified for bioinformatics services.
Multiple biomarker platforms +
Our data analysis expertise spans across multiple biomarker technological platforms such as genetics, transcriptomics, protein assays and cellular assays.
Biomarker study design +
In every study, the design is key. It is particularly true in exploratory biomarker studies, where statistical power cannot be controlled and where sample logisitics can have an important impact on input data quality and availability.
Statistical analysis plan +
The Statistical Analysis Plan (SAP) is the blueprint of the analysis that will be performed.
Biomarker Data Management +
Biomarker data management is a key step in every clinical bioinformatics study. Approximately 40% of the overall analysis time is dedicated to these tasks, which are crucial for the quality of the overall analysis.
Patient Stratification Analyses +
A stratification analysis aims at identifying sub-populations of patients where the likelihood of observing a given phenotype (e.g. disease evolution, response to treatment etc) is increased. The patients sub-populations are defined using on one or more biomarkers.
Pharmacodynamic Analyses +
A pharmacodynamic analysis aims at identifying biomarkers measured over time, whose change in expression levels is correlated with the drug administration and dose.Biomarkers identified by this analysis may give important insights on the mode of action of a drug, and can ultimately become predictive markers if their changes are correlated with clinical efficacy (surrogate biomarkers).
Quality Control +
Biomarker data are heterogeneous. Technology-specific quality controls must be applied in order to identify possible sources of bias that could impact the analysis. The biology behind the assay and the sample logistics in clinical settings are two of the most important factors that can impact the biomarker data quality.
Biological assessment +
Numbers are nothing without the biology which is behind. All results from our data analysis projects are reviewed from a biological perspective.
Tailored Visualizations +
A picture is worth a thousand words. This is particularly true for complex biological data. Drawing constructive conclusions from a biomarker analysis requires adapted visualisation methods, aligned to the objectives of the analysis. We use our biotechnological and computational expertise to provide the best graphical representation for your data.
Exploratory biomarker data analyses generate hypotheses that can be used years later to support a submission. Ensuring proper archiving and retrieval of raw data, derived data, and results, is therefore instrumental in the biomarker development process.
Publication support +
As the data scientists analysing your data, we are in the best position to support the publication of your results (patents, posters, articles). We generate customised figures, tables, and listings that bring out your data.